細胞鐵死亡(Ferroptosis)相關產品線熱賣中-優寧維(univ)官網
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細胞鐵死亡(Ferroptosis)相關產品線熱賣中

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細胞鐵死亡(Ferroptosis)是一種鐵依賴性脂質過氧化物積累所引發的新型細胞死亡方式。鐵離子極大地加速了脂肪酸的過氧化反應,脂質過氧化物在鐵的調控下累計,這些脂質reactive oxygen species(ROS)超出細胞抗氧化系統的承受能力,氧化過程損傷胞內蛋白、核酸和脂質,導致細胞死亡。

常規細胞凋亡或壞死常常伴隨著細胞器腫大、染色質聚合、細胞膜完整性下降等特征,而細胞鐵死亡在細胞形態上引起的改變甚微,往往只伴隨細胞體積略微減小、線粒體膜密度增加等。



引發鐵死亡通路(ferroptotic pathway)關鍵因素:

? ★ 貯藏在磷脂膜中的多不飽和長鏈脂肪酸(PUFAs)
? ★ 可氧化還原的鐵離子
? ★ 有缺陷的脂質過氧化修復系統

在癌癥研究領域中,Ferroptosis suppressor protein 1(FSP1) Glutathione peroxidase 4(GPX4)已成為重要研究靶點。FSP1和GPX4作為細胞鐵死亡通路的負調節因子,阻礙細胞鐵死亡。其FSP1和GPX4抑制劑則能有效激活癌細胞的鐵死亡,該類抑制劑的藥物篩選也已成為研究新型抗癌治療方法的熱點項目。


Ferroptosis分子機制與信號通路圖:


優寧維為您提供全面、優質、方便快捷的Ferroptosis相關產品線??!



其中優寧維代理的Cayman公司最新上市的FSP1 Fluorescent Inhibitor Screening Assay kit(Item No.701900)和GPX4 Inhibitor Screening Assay Kit(Item No.701880)。該分析試劑盒是市場上第一款能提供方便快捷FSP1和GPX4新型抑制劑藥物篩選的產品,為發現鐵死亡相關新型抗癌藥物提供便利。

Identify Novel Inducers of Ferroptosis
GPX4 Inhibitor?
Screening Assay Kit
Item No. 701880
- Includes recombinant human GPX4 and positive control GPX4 inhibitor ML-162
- Assay 45 samples in duplicate or 29 samples in triplicate
- Plate-based colorimetric measurement (340nm)
FSP1 Fluorescent Inhibitor
Screening Assay Kit
Item No. 701900
- Includes recombinant human FSP1 and positive control FSP1 inhibitor iFSP1
- Assay 45 samples in duplicate or 29 samples in triplicate
- Plate-based colorimetric measurement (590nm)

除了以上兩個首發的試劑盒以外,我們還可提供鐵死亡相關產品線:抑制劑與誘導劑,氧化磷脂,檢測試劑盒,抗體,探針等。

Ferroptosis產品線部分商品:

抑制劑與誘導劑(Inhibitors&Inducers)

貨號

抑制劑與誘導劑(Inhibitors&Inducers)

28966

PKUMDL-LC-101-DO4

11884

Rosiglitazone(maleate)

31002

Pantothenate Kinase Inhibitor

10009644

Sorafenib

氧化磷脂

(Oxidized lipids)

貨號

氧化磷脂(Oxidized Phospholipids)

21138

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

21139

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

26531

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

25856

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

檢測類商品

(Assay products)

貨號

GPX檢測(GPX Detection)

703102

Glutathione Peroxidase Assay Kit

26906

GPX4(human,recombinant);selenocysteine incorporation confirmed by MS

10005258

GPX4 Polyclonal Antibody

貨號

GSH活性檢測(GSH Activity Assays)

703002

Glutathione Assay Kit

600360

Glutathione Cell-Based Detection Kit(Blue Fluorescence)

703202

Glutathione Reductase Assay Kit

貨號

FSP1檢測(FSP1 Detection)

29611

FSP1 (human, recombinant)

29554

Coumarin-Quinone Conjugate

貨號

脂氧合酶&抑制劑篩選(Lipoxygenases & Inhibitor Screening Assay)

60402

5-Lipoxygenase (human, recombinant)

10341

12-Lipoxygenase (platelet-type, mouse recombinant)

10011263

15-Lipoxygenase-2 (human recombinant)

760700

Lipoxygenase Inhibitor Screening Assay Kit

貨號

脂質ROS檢測試劑盒(Lipid ROS Assay Kits)

501140

DHN-MA EIA Kit

705002

Lipid Hydroperoxide (LPO) Assay Kit

601290

ROS Detection Cell-Based Assay Kit (DHE)

10009055

TBARS Assay Kit

抗體類商品

(Antibodies)

貨號

GSH衍生物和抗體(GSH Derivatives and Antibodies)

14953

Glutathione ethyl ester

10007461

L-Glutathione,reduced

10010013

Glutathione S-Transferase Polyclonal Antibody

4393S

FTH1 (D1D4) Rabbit mAb

19689S

Cystathionine γ-Lyase (D1N1D) Rabbit mAb

52455S

GPX4 Antibody

43966S

HO-1 (E3F4S) Rabbit mAb

58135S

LOX (D8F2K) Rabbit mAb

66849S

NCOA4 (E8H8Z) Rabbit mAb

20272S

IRP1 (D6S4J) Rabbit mAb

37135S

IRP2 (D6E6W) Rabbit mAb

12282S

Cox2 (D5H5) XP? Rabbit mAb

12691S

xCT/SLC7A11 (D2M7A) Rabbit mAb

探針

(Probe)

貨號

脂質ROS探針(Lipid ROS Probes)

27086

C11 BODIPY 581/591

62237

DPPP

13265

4-hydroxy Nonenal Alkyne

其他化合物產品

(Others)

貨號

脂質過氧化物(Lipid Peroxidation End Products)

10004413

4-hydroperoxy 2-Nonenal

32100

4-hydroxy Nonenal

10185

4-oxo-2-Nonenal

10627

4-hydroxy Nonenal Glutathione (trifluoroacetate salt)

32110

4-hydroxy Nonenal Mercapturic Acid

貨號

親脂抗氧化劑(Lipophilic Antioxidants)

89910

BHT

81880

tetrahydro-L-Biopterin (hydrochloride)

11506

Coenzyme Q10

70530

Ebselen

15475

Idebenone

10008377

α-Tocotrienol

10011659

Trolox


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